Reaction Details Report a problem with these data
Target
Neutrophil collagenase
Ligand
BDBM50062342
Substrate
n/a
Meas. Tech.
ChEMBL_105205 (CHEMBL713844)
Ki
0.64±n/a nM
Citation
 Levy, DE; Lapierre, F; Liang, W; Ye, W; Lange, CW; Li, X; Grobelny, D; Casabonne, M; Tyrrell, D; Holme, K; Nadzan, A; Galardy, RE Matrix metalloproteinase inhibitors: a structure-activity study. J Med Chem 41:199-223 (1998) [PubMed]  Article 
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM50062342
Synonyms:
(R)-N*4*-Hydroxy-2-isobutyl-N*1*-((R)-1-methylcarbamoyl-2-naphthalen-1-yl-ethyl)-succinamide | CHEMBL70492
Type:
Small organic molecule
Emp. Form.:
C22H29N3O4
Mol. Mass.:
399.4834
SMILES:
CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO
Structure:
Search PDB for entries with ligand similarity: