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TargetMetabotropic glutamate receptor 2
LigandBDBM50062520
Substrate/Competitorn/a
Meas. Tech.ChEMBL_106035
IC50 180±n/a nM
Citation Ornstein, PLBleisch, TJArnold, MBKennedy, JHWright, RAJohnson, BGTizzano, JPHelton, DRKallman, MJSchoepp, DDHérin, M 2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability. J Med Chem41:358-78 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Metabotropic glutamate receptor 2
Name:Metabotropic glutamate receptor 2
Synonyms:GRM2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | mGluR2 | metabotropic glutamate 2
Type:Enzyme
Mol. Mass.:95584.88
Organism:Homo sapiens (Human)
Description:Q14416
Residue:872
Sequence:
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50062520
NameBDBM50062520
Synonyms:(1S,2S)-2-((R)-1-Amino-1-carboxy-3-m-tolyl-propyl)-cyclopropanecarboxylic acid | CHEMBL124501
TypeSmall organic molecule
Emp. Form.C15H19NO4
Mol. Mass.277.3157
SMILESCc1cccc(CC[C@@](N)([C@H]2C[C@@H]2C(O)=O)C(O)=O)c1
Structure
n/a