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Target
D(3) dopamine receptor
Ligand
BDBM50063282
Substrate
n/a
Meas. Tech.
ChEMBL_62432 (CHEMBL674835)
Ki
160±n/a nM
Citation
 Wustrow, D; Belliotti, T; Glase, S; Kesten, SR; Johnson, D; Colbry, N; Rubin, R; Blackburn, A; Akunne, H; Corbin, A; Davis, MD; Georgic, L; Whetzel, S; Zoski, K; Heffner, T; Pugsley, T; Wise, L Aminopyrimidines with high affinity for both serotonin and dopamine receptors. J Med Chem 41:760-71 (1998) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50063282
Synonyms:
CHEMBL2110308 | {4-[2-(4-Phenyl-piperazin-1-yl)-ethyl]-cyclohexyl}-pyrimidin-2-yl-amine
Type:
Small organic molecule
Emp. Form.:
C20H27N5
Mol. Mass.:
337.4619
SMILES:
C1CC(CCC1Nc1ncccn1)N1CCN(CC1)c1ccccc1 |(8.5,-10.43,;10.04,-10.36,;10.74,-8.99,;9.9,-7.69,;8.36,-7.77,;7.66,-9.13,;6.12,-9.2,;5.28,-7.92,;3.77,-7.99,;2.93,-6.71,;3.63,-5.33,;5.17,-5.26,;6.01,-6.54,;12.28,-8.9,;13.12,-10.21,;14.66,-10.13,;15.34,-8.75,;14.5,-7.45,;12.98,-7.54,;16.88,-8.67,;17.72,-9.95,;19.24,-9.86,;19.94,-8.5,;19.09,-7.21,;17.56,-7.31,)|
Structure:
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