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Target
D(3) dopamine receptor
Ligand
BDBM50063293
Substrate
n/a
Meas. Tech.
ChEMBL_62432 (CHEMBL674835)
Ki
210±n/a nM
Citation
 Wustrow, D; Belliotti, T; Glase, S; Kesten, SR; Johnson, D; Colbry, N; Rubin, R; Blackburn, A; Akunne, H; Corbin, A; Davis, MD; Georgic, L; Whetzel, S; Zoski, K; Heffner, T; Pugsley, T; Wise, L Aminopyrimidines with high affinity for both serotonin and dopamine receptors. J Med Chem 41:760-71 (1998) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50063293
Synonyms:
CHEMBL165689 | Pyrimidin-2-yl-{4-[2-(2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-yl)-ethyl]-cyclohexyl}-amine
Type:
Small organic molecule
Emp. Form.:
C20H29N7
Mol. Mass.:
367.4912
SMILES:
C(CN1CCN(CC1)c1cnccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1 |wU:17.22,wD:14.15,(9.2,-6.02,;10.04,-7.31,;11.58,-7.23,;12.42,-8.52,;13.96,-8.45,;14.65,-7.08,;13.82,-5.79,;12.28,-5.86,;16.19,-6.98,;16.87,-5.63,;18.39,-5.54,;19.25,-6.82,;18.55,-8.17,;17.01,-8.27,;7.67,-6.1,;6.83,-4.81,;5.3,-4.88,;4.6,-6.25,;5.44,-7.54,;6.97,-7.47,;3.06,-6.31,;2.22,-5.02,;.7,-5.11,;-.13,-3.81,;.57,-2.43,;2.11,-2.36,;2.94,-3.66,)|
Structure:
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