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Target
Cyclin-C
Ligand
BDBM50509567
Substrate
n/a
Meas. Tech.
ChEMBL_1838809 (CHEMBL4338942)
IC50
1.000000±n/a nM
Citation
 Grandjean, JM; Jiu, AY; West, JW; Aoyagi, A; Droege, DG; Elepano, M; Hirasawa, M; Hirouchi, M; Murakami, R; Lee, J; Sasaki, K; Hirano, S; Ohyama, T; Tang, BC; Vaz, RJ; Inoue, M; Olson, SH; Prusiner, SB; Conrad, J; Paras, NA Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity. ACS Med Chem Lett 11:127-132 (2020) [PubMed]  Article 
Target
Name:
Cyclin-C
Synonyms:
CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:
PROTEIN
Mol. Mass.:
33244.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107900
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM50509567
Synonyms:
CHEMBL4455382 | US11213520, Example I-003
Type:
Small organic molecule
Emp. Form.:
C22H20N4O
Mol. Mass.:
356.4204
SMILES:
CN(C)C(=O)Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccccc12
Structure:
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