Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50063703
Substrate
n/a
Meas. Tech.
ChEMBL_212344 (CHEMBL818267)
IC50
15300±n/a nM
Citation
 Hays, SJ; Caprathe, BW; Gilmore, JL; Amin, N; Emmerling, MR; Michael, W; Nadimpalli, R; Nath, R; Raser, KJ; Stafford, D; Watson, D; Wang, K; Jaen, JC 2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease. J Med Chem 41:1060-7 (1998) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:
Enzyme
Mol. Mass.:
25790.52
Organism:
Bos taurus (bovine)
Description:
P00760
Residue:
246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
  
Inhibitor
Name:
BDBM50063703
Synonyms:
2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEMBL10378
Type:
Small organic molecule
Emp. Form.:
C14H8INO2
Mol. Mass.:
349.1233
SMILES:
Ic1ccccc1-c1nc2ccccc2c(=O)o1
Structure:
Search PDB for entries with ligand similarity: