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Target
Dihydrofolate reductase
Ligand
BDBM50063979
Substrate
n/a
Meas. Tech.
ChEMBL_53136 (CHEMBL665857)
IC50
>27000±n/a nM
Citation
 Gangjee, A; Guo, X; Queener, SF; Cody, V; Galitsky, N; Luft, JR; Pangborn, W Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines. J Med Chem 41:1263-71 (1998) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
23891.29
Organism:
Pneumocystis carinii
Description:
n/a
Residue:
206
Sequence:
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL
  
Inhibitor
Name:
BDBM50063979
Synonyms:
5-{[(2,5-Dimethoxy-phenyl)-methyl-amino]-methyl}-furo[2,3-d]pyrimidine-2,4-diamine | CHEMBL23054
Type:
Small organic molecule
Emp. Form.:
C16H19N5O3
Mol. Mass.:
329.3538
SMILES:
COc1ccc(OC)c(c1)N(C)Cc1coc2nc(N)nc(N)c12
Structure:
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