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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50064961
Substrate
n/a
Meas. Tech.
ChEMBL_200965 (CHEMBL802053)
Ki
3.92±n/a nM
Citation
 Huang, Y; Hammond, PS; Whirrett, BR; Kuhner, RJ; Wu, L; Childers, SR; Mach, RH Synthesis and quantitative structure-activity relationships of N-(1-benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective sigma1 receptor ligands. J Med Chem 41:2361-70 (1998) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50064961
Synonyms:
CHEMBL77953 | N-(1-Benzyl-piperidin-4-yl)-2-(3-trifluoromethyl-phenyl)-acetamide
Type:
Small organic molecule
Emp. Form.:
C21H23F3N2O
Mol. Mass.:
376.4153
SMILES:
FC(F)(F)c1cccc(CC(=O)NC2CCN(Cc3ccccc3)CC2)c1
Structure:
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