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Target
Neutrophil elastase
Ligand
BDBM50065866
Substrate
n/a
Meas. Tech.
ChEMBL_63639 (CHEMBL675350)
IC50
300±n/a nM
Citation
 Yoakim, C; Ogilvie, WW; Cameron, DR; Chabot, C; Guse, I; Haché, B; Naud, J; O'Meara, JA; Plante, R; Déziel, R beta-Lactam derivatives as inhibitors of human cytomegalovirus protease. J Med Chem 41:2882-91 (1998) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50065866
Synonyms:
(2S,3S)-3-Allyl-2-benzyl-4-oxo-azetidine-1-carboxylic acid (pyridin-4-ylmethyl)-amide | CHEMBL95813
Type:
Small organic molecule
Emp. Form.:
C20H21N3O2
Mol. Mass.:
335.3996
SMILES:
C=CC[C@H]1[C@H](Cc2ccccc2)N(C(=O)NCc2ccncc2)C1=O
Structure:
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