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Target
Transient receptor potential cation channel subfamily A member 1
Ligand
BDBM50164168
Substrate
n/a
Meas. Tech.
ChEMBL_1846734 (CHEMBL4347275)
EC50
169824±n/a nM
Citation
 Chandrabalan, A; McPhillie, MJ; Morice, AH; Boa, AN; Sadofsky, LR N-Cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites. Eur J Med Chem 170:141-156 (2019) [PubMed]  Article 
Target
Name:
Transient receptor potential cation channel subfamily A member 1
Synonyms:
ANKTM1 | Ankyrin-like with transmembrane domains protein 1 | TRPA1 | TRPA1_HUMAN | Transformation-sensitive protein p120 | Transient receptor potential cation channel subfamily A member 1 (TRPA1)
Type:
Protein
Mol. Mass.:
127514.20
Organism:
Homo sapiens (Human)
Description:
O75762
Residue:
1119
Sequence:
MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIFCFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETEDDDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
  
Inhibitor
Name:
BDBM50164168
Synonyms:
1,3,4-Eugenol | 1-Hydroxy-2-methoxy-4-allylbenzene | 1-Hydroxy-2-methoxy-4-prop-2-enylbenzene | 1-Hydroxy-2-methoxy-4-propenylbenzene | 1-allyl-3-methoxy-4-hydroxybenzene | 1-allyl-4-hydroxy-3-methoxybenzene | 2-Hydroxy-5-allylanisole | 2-Methoxy-1-hydroxy-4-allylbenzene | 2-Methoxy-4-allylphenol | 2-Methoxy-4-prop-2-enylphenol | 2-methoxy-4-(prop-2-en-1-yl)phenol4-allyl-2-methoxyphenol | 4-Allyl-1-hydroxy-2-methoxybenzene | 4-Allylcatechol-2-methyl ether | 4-Allylguaiacol | 4-Hydroxy-3-methoxy-1-allylbenzene | Allylguaiacol | CHEMBL42710 | Caryophyllic acid | Eugenic acid | Eugenol | p-Allylguaiacol | p-Eugenol
Type:
Small organic molecule
Emp. Form.:
C10H12O2
Mol. Mass.:
164.2011
SMILES:
COc1cc(CC=C)ccc1O
Structure:
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