Reaction Details Report a problem with these data
Target
Telomerase reverse transcriptase
Ligand
BDBM50068331
Substrate
n/a
Meas. Tech.
ChEMBL_210069 (CHEMBL813593)
IC50
>50000±n/a nM
Citation
Perry, PJ; Reszka, AP; Wood, AA; Read, MA; Gowan, SM; Dosanjh, HS; Trent, JO; Jenkins, TC; Kelland, LR; Neidle, S Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones. J Med Chem 41:4873-84 (1998) [PubMed] Article
More Info.:
Target
Name:
Telomerase reverse transcriptase
Synonyms:
EST2 | TCS1 | TERT | TERT_HUMAN | TRT
Type:
PROTEIN
Mol. Mass.:
127099.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1447029
Residue:
1132
Sequence:
MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRRGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRLVETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVTPAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
Inhibitor
Name:
BDBM50068331
Synonyms:
3-Morpholin-4-yl-N-[5-(3-morpholin-4-yl-propionylamino)-9,10-dioxo-9,10-dihydro-anthracen-1-yl]-propionamide | CHEMBL144411
Type:
Small organic molecule
Emp. Form.:
C28H32N4O6
Mol. Mass.:
520.5769
SMILES:
O=C(CCN1CCOCC1)Nc1cccc2C(=O)c3c(NC(=O)CCN4CCOCC4)cccc3C(=O)c12