Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50069667
Substrate
n/a
Meas. Tech.
ChEBML_64135
Ki
2±n/a nM
Citation
 Burkhart, JP; Mehdi, S; Koehl, JR; Angelastro, MR; Bey, P; Peet, NP Preparation of alpha-keto ester enol acetates as potential prodrugs of human neutrophil elastase inhibitors. Bioorg Med Chem Lett 8:63-4 (1999) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50069667
Synonyms:
(S)-3-{[1-((S)-2-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-propionylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-methyl-2-oxo-pentanoic acid methyl ester | CHEMBL157261
Type:
Small organic molecule
Emp. Form.:
C32H38ClN5O10S
Mol. Mass.:
720.19
SMILES:
COC(=O)C(=O)[C@@H](NC(=O)C1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(Cl)cc1)C(C)C
Structure:
Search PDB for entries with ligand similarity: