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Target
Substance-K receptor
Ligand
BDBM50030432
Substrate
n/a
Meas. Tech.
ChEBML_142715
IC50
>5000±n/a nM
Citation
 Qi, H; Shah, SK; Cascieri, MA; Sadowski, SJ; MaCcoss, M L-tryptophan urea amides as NK1/NK2 dual antagonists. Bioorg Med Chem Lett 8:2259-62 (1999) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM50030432
Synonyms:
CHEMBL305608 | N-[(S)-1-[(3,5-Dimethyl-benzyl)-methyl-carbamoyl]-2-(1H-indol-3-yl)-ethyl]-benzamide
Type:
Small organic molecule
Emp. Form.:
C28H29N3O2
Mol. Mass.:
439.5488
SMILES:
CN(Cc1cc(C)cc(C)c1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1
Structure:
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