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Target
Tissue alpha-L-fucosidase
Ligand
BDBM50072682
Substrate
n/a
Meas. Tech.
ChEMBL_216126 (CHEMBL816946)
IC50
190±n/a nM
Citation
 Wischnat, R; Martin, R; Takayama, S; Wong, CH Chemoenzymatic synthesis of iminocyclitol derivatives: a useful library strategy for the development of selective fucosyltransfer enzymes inhibitors. Bioorg Med Chem Lett 8:3353-8 (1999) [PubMed]  Article 
Target
Name:
Tissue alpha-L-fucosidase
Synonyms:
Alpha-L-fucosidase I | Alpha-L-fucoside fucohydrolase | FUCA1 | FUCO_HUMAN | Tissue alpha-L-fucosidase
Type:
PROTEIN
Mol. Mass.:
53690.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_34088
Residue:
466
Sequence:
MRAPGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGVFIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEWADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
  
Inhibitor
Name:
BDBM50072682
Synonyms:
CHEMBL115930 | {[(3,4,5-Trihydroxy-2-hydroxymethyl-6-methyl-piperidin-2-ylmethyl)-carbamoyl]-methyl}-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C18H27N3O7
Mol. Mass.:
397.4229
SMILES:
CC1NC(CO)(CNC(=O)CNC(=O)OCc2ccccc2)C(O)C(O)C1O
Structure:
Search PDB for entries with ligand similarity: