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Target
Alpha-1A adrenergic receptor
Ligand
BDBM50073025
Substrate
n/a
Meas. Tech.
ChEMBL_33748 (CHEMBL647825)
Ki
1.1±n/a nM
Citation
 Barlocco, D; Cignarella, G; Montesano, F; Leonardi, A; Mella, M; Toma, L Novel adrenoceptor antagonists with a tricyclic pyrrolodipyridazine skeleton. J Med Chem 42:173-7 (1999) [PubMed]  Article 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:
Cell-surface receptors
Mol. Mass.:
51511.67
Organism:
Homo sapiens (Human)
Description:
P35348
Residue:
466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
  
Inhibitor
Name:
BDBM50073025
Synonyms:
8-Chloro-2-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethylamino}-6-methyl-6H-1,6,7,9a-tetraaza-fluoren-5-one | CHEMBL301078
Type:
Small organic molecule
Emp. Form.:
C23H26ClN7O2
Mol. Mass.:
467.951
SMILES:
COc1ccccc1N1CCN(CCNc2ccc3c4c(cn3n2)c(Cl)nn(C)c4=O)CC1
Structure:
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