Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50073562
Substrate
n/a
Meas. Tech.
ChEMBL_61584 (CHEMBL675756)
IC50
>1000±n/a nM
Citation
Leonardi, A; Motta, G; Boi, C; Testa, R; Poggesi, E; De Benedetti, PG; Menziani, MC Synthesis, pharmacological evaluation, and structure-activity relationship and quantitative structure-activity relationship studies on novel derivatives of 2,4-diamino-6,7-dimethoxyquinazoline alpha1-adrenoceptor antagonists. J Med Chem 42:427-37 (1999) [PubMed] Article
More Info.:
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
Inhibitor
Name:
BDBM50073562
Synonyms:
1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-2-(2-isopropyl-6-methoxy-phenoxy)-2-methyl-propan-1-one | CHEMBL435591
Type:
Small organic molecule
Emp. Form.:
C28H37N5O5
Mol. Mass.:
523.6239
SMILES:
COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C(C)(C)Oc1c(OC)cccc1C(C)C