Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50074447
Substrate
n/a
Meas. Tech.
ChEMBL_51114 (CHEMBL664960)
Ki
4.4±n/a nM
Citation
 Chorvat, RJ; Bakthavatchalam, R; Beck, JP; Gilligan, PJ; Wilde, RG; Cocuzza, AJ; Hobbs, FW; Cheeseman, RS; Curry, M; Rescinito, JP; Krenitsky, P; Chidester, D; Yarem, JA; Klaczkiewicz, JD; Hodge, CN; Aldrich, PE; Wasserman, ZR; Fernandez, CH; Zaczek, R; Fitzgerald, LW; Huang, SM; Shen, HL; Wong, YN; Chien, BM; Arvanitis, A Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines. J Med Chem 42:833-48 (1999) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50074447
Synonyms:
Butyl-[3-(2-chloro-4,6-dimethoxy-phenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-ethyl-amine | CHEMBL168676
Type:
Small organic molecule
Emp. Form.:
C19H25ClN6O2
Mol. Mass.:
404.894
SMILES:
CCCCN(CC)c1nc(C)nc2n(nnc12)-c1c(Cl)cc(OC)cc1OC |(15.38,-2.71,;14.03,-1.94,;12.71,-2.71,;11.37,-1.94,;10.04,-2.71,;8.7,-1.94,;8.7,-.4,;10.04,-4.25,;8.7,-5.02,;8.7,-6.55,;7.36,-7.32,;10.04,-7.32,;11.37,-6.55,;12.82,-7.04,;13.73,-5.79,;12.82,-4.55,;11.37,-5.02,;13.15,-8.54,;14.62,-9,;15.76,-7.98,;14.94,-10.51,;13.8,-11.54,;14.15,-13.05,;13.01,-14.1,;12.33,-11.07,;12.01,-9.56,;10.54,-9.09,;9.4,-10.13,)|
Structure:
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