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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50076079
Substrate
n/a
Meas. Tech.
ChEBML_139845
Ki
353±n/a nM
Citation
 Doller, D; Chackalamannil, S; Czarniecki, M; McQuade, R; Ruperto, V Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists. Bioorg Med Chem Lett 9:901-6 (1999) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50076079
Synonyms:
(3S,3aR,4R,4aS,8aR,9aS)-4-[3-(2,5-Dimethyl-piperazin-1-yl)-propyl]-3-methyl-decahydro-naphtho[2,3-c]furan-1-one | CHEMBL355193
Type:
Small organic molecule
Emp. Form.:
C22H38N2O2
Mol. Mass.:
362.5493
SMILES:
C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CC(C)NCC3C)[C@@H]12
Structure:
Search PDB for entries with ligand similarity: