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Target
Neutrophil elastase
Ligand
BDBM50077011
Substrate
n/a
Meas. Tech.
ChEBML_63657
IC50
17000±n/a nM
Citation
 Arcadi, A; Asti, C; Brandolini, L; Caselli, G; Marinelli, F; Ruggieri, V Synthesis and in vitro and in vivo evaluation of the 2-(6'methoxy-3',4'-dihydro-1'-naphtyl)-4H-3,1-benzoxazin-4- one as a new potent substrate inhibitor of human leukocyte elastase. Bioorg Med Chem Lett 9:1291-4 (1999) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50077011
Synonyms:
2-Phenyl-4H-3,1-benzoxazin-4-one (3) | 2-Phenyl-benzo[d][1,3]oxazin-4-one | CHEMBL24449
Type:
Small organic molecule
Emp. Form.:
C14H9NO2
Mol. Mass.:
223.2268
SMILES:
O=c1oc(nc2ccccc12)-c1ccccc1
Structure:
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