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Target
Proteinase-activated receptor 1
Ligand
BDBM50077754
Substrate
n/a
Meas. Tech.
ChEBML_209265
EC50
2600±n/a nM
Citation
 McComsey, DF; Hawkins, MJ; Andrade-Gordon, P; Addo, MF; Oksenberg, D; Maryanoff, BE Heterocycle-peptide hybrid compounds. Aminotriazole-containing agonists of the thrombin receptor (PAR-1). Bioorg Med Chem Lett 9:1423-8 (1999) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50077754
Synonyms:
(S)-2-[(S)-3-Cyclohexyl-2-((E)-3-pyridin-3-yl-acryloylamino)-propionylamino]-5-guanidino-pentanoic acid ((S)-1-carbamoyl-2-phenyl-ethyl)-amide | CHEMBL33742
Type:
Small organic molecule
Emp. Form.:
C32H44N8O4
Mol. Mass.:
604.743
SMILES:
NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)C=Cc1cccnc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |w:23.24|
Structure:
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