Target
5-hydroxytryptamine receptor 1B
Ligand
BDBM50065421
Substrate
n/a
Meas. Tech.
ChEMBL_1600 (CHEMBL616626)
EC50
440±n/a nM
Citation
 van Niel, MBCollins, IBeer, MSBroughton, HBCheng, SKGoodacre, SCHeald, ALocker, KLMacLeod, AMMorrison, DMoyes, CRO'Connor, DPike, ARowley, MRussell, MGSohal, BStanton, JAThomas, SVerrier, HWatt, APCastro, JL Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles. J Med Chem 42:2087-104 (1999) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1B
Synonyms:
5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43579.17
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells
Residue:
390
Sequence:
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
  
Inhibitor
Name:
BDBM50065421
Synonyms:
3-(3-{4-Fluoro-4-[2-(3-fluoro-phenyl)-ethyl]-piperidin-1-yl}-propyl)-5-[1,2,4]triazol-4-yl-1H-indole | CHEMBL63799
Type:
Small organic molecule
Emp. Form.:
C26H29F2N5
Mol. Mass.:
449.5388
SMILES:
Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(cc34)-n3cnnc3)CC2)c1
Structure:
Search PDB for entries with ligand similarity: