Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1B
Ligand
BDBM50077806
Substrate
n/a
Meas. Tech.
ChEMBL_1600 (CHEMBL616626)
EC50
510±n/a nM
Citation
 van Niel, MB; Collins, I; Beer, MS; Broughton, HB; Cheng, SK; Goodacre, SC; Heald, A; Locker, KL; MacLeod, AM; Morrison, D; Moyes, CR; O'Connor, D; Pike, A; Rowley, M; Russell, MG; Sohal, B; Stanton, JA; Thomas, S; Verrier, H; Watt, AP; Castro, JL Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles. J Med Chem 42:2087-104 (1999) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1B
Synonyms:
5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43579.17
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells
Residue:
390
Sequence:
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
  
Inhibitor
Name:
BDBM50077806
Synonyms:
3-{3-[4-Fluoro-4-(2-phenyl-propyl)-piperidin-1-yl]-propyl}-5-[1,2,4]triazol-4-yl-1H-indole | CHEMBL67684
Type:
Small organic molecule
Emp. Form.:
C27H32FN5
Mol. Mass.:
445.5749
SMILES:
CC(CC1(F)CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: