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Target
Acetolactate synthase, chloroplastic
Ligand
BDBM50079604
Substrate
n/a
Meas. Tech.
ChEBML_27494
IC50
>309000±n/a nM
Comments
modified from >0.000309 20220121
Citation
 Liu, J; Li, Z; Yan, H; Wang, L; Chen, J The design and synthesis of ALS inhibitors from pharmacophore models. Bioorg Med Chem Lett 9:1927-32 (1999) [PubMed]  Article 
Target
Name:
Acetolactate synthase, chloroplastic
Synonyms:
AHAS | ALS | Acetolactate synthase | CSR1 | ILVB_ARATH | TZP5
Type:
PROTEIN
Mol. Mass.:
72585.19
Organism:
Arabidopsis thaliana
Description:
ChEMBL_934103
Residue:
670
Sequence:
MAAATTTTTTSSSISFSTKPSPSSSKSPLPISRFSLPFSLNPNKSSSSSRRRGIKSSSPSSISAVLNTTTNVTTTPSPTKPTKPETFISRFAPDQPRKGADILVEALERQGVETVFAYPGGASMEIHQALTRSSSIRNVLPRHEQGGVFAAEGYARSSGKPGICIATSGPGATNLVSGLADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVEDIPRIIEEAFFLATSGRPGPVLVDVPKDIQQQLAIPNWEQAMRLPGYMSRMPKPPEDSHLEQIVRLISESKKPVLYVGGGCLNSSDELGRFVELTGIPVASTLMGLGSYPCDDELSLHMLGMHGTVYANYAVEHSDLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDSAEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRNELNVQKQKFPLSFKTFGEAIPPQYAIKVLDELTDGKAIISTGVGQHQMWAAQFYNYKKPRQWLSSGGLGAMGFGLPAAIGASVANPDAIVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVMQWEDRFYKANRAHTFLGDPAQEDEIFPNMLLFAAACGIPAARVTKKADLREAIQTMLDTPGPYLLDVICPHQEHVLPMIPSGGTFNDVITEGDGRIKY
  
Inhibitor
Name:
BDBM50079604
Synonyms:
2,5-Dichloro-N-(5-methyl-thiazol-2-yl)-benzenesulfonamide | CHEMBL58341
Type:
Small organic molecule
Emp. Form.:
C10H8Cl2N2O2S2
Mol. Mass.:
323.219
SMILES:
Cc1cnc(NS(=O)(=O)c2cc(Cl)ccc2Cl)s1
Structure:
Search PDB for entries with ligand similarity: