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Target
Acetolactate synthase, chloroplastic
Ligand
BDBM50079609
Substrate
n/a
Meas. Tech.
ChEBML_27494
IC50
39000±n/a nM
Comments
modified from 0.000039 20220121
Citation
 Liu, J; Li, Z; Yan, H; Wang, L; Chen, J The design and synthesis of ALS inhibitors from pharmacophore models. Bioorg Med Chem Lett 9:1927-32 (1999) [PubMed]  Article 
Target
Name:
Acetolactate synthase, chloroplastic
Synonyms:
AHAS | ALS | Acetolactate synthase | CSR1 | ILVB_ARATH | TZP5
Type:
PROTEIN
Mol. Mass.:
72585.19
Organism:
Arabidopsis thaliana
Description:
ChEMBL_934103
Residue:
670
Sequence:
MAAATTTTTTSSSISFSTKPSPSSSKSPLPISRFSLPFSLNPNKSSSSSRRRGIKSSSPSSISAVLNTTTNVTTTPSPTKPTKPETFISRFAPDQPRKGADILVEALERQGVETVFAYPGGASMEIHQALTRSSSIRNVLPRHEQGGVFAAEGYARSSGKPGICIATSGPGATNLVSGLADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVEDIPRIIEEAFFLATSGRPGPVLVDVPKDIQQQLAIPNWEQAMRLPGYMSRMPKPPEDSHLEQIVRLISESKKPVLYVGGGCLNSSDELGRFVELTGIPVASTLMGLGSYPCDDELSLHMLGMHGTVYANYAVEHSDLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDSAEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRNELNVQKQKFPLSFKTFGEAIPPQYAIKVLDELTDGKAIISTGVGQHQMWAAQFYNYKKPRQWLSSGGLGAMGFGLPAAIGASVANPDAIVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVMQWEDRFYKANRAHTFLGDPAQEDEIFPNMLLFAAACGIPAARVTKKADLREAIQTMLDTPGPYLLDVICPHQEHVLPMIPSGGTFNDVITEGDGRIKY
  
Inhibitor
Name:
BDBM50079609
Synonyms:
4-Fluoro-N-(4-methyl-pyrimidin-2-yl)-benzenesulfonamide | CHEMBL300344
Type:
Small organic molecule
Emp. Form.:
C11H10FN3O2S
Mol. Mass.:
267.279
SMILES:
Cc1ccnc(NS(=O)(=O)c2ccc(F)cc2)n1
Structure:
Search PDB for entries with ligand similarity: