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Target
M-phase inducer phosphatase 1
Ligand
BDBM50080998
Substrate
n/a
Meas. Tech.
ChEBML_49006
IC50
1000000±n/a nM
Citation
 Blanchard, JL; Epstein, DM; Boisclair, MD; Rudolph, J; Pal, K Dysidiolide and related gamma-hydroxy butenolide compounds as inhibitors of the protein tyrosine phosphatase, CDC25. Bioorg Med Chem Lett 9:2537-8 (1999) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 1
Synonyms:
CDC25A | Dual specificity phosphatase (Cdc25A) | Dual specificity phosphatase Cdc25A | M-phase inducer phosphatase 1 | MPIP1_HUMAN | phosphatase Cdc25
Type:
Protein
Mol. Mass.:
59090.18
Organism:
Homo sapiens (Human)
Description:
P30304
Residue:
524
Sequence:
MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL
  
Inhibitor
Name:
BDBM50080998
Synonyms:
6-(2-Hydroxy-5-oxo-2,5-dihydro-furan-3-yl)-3-[(E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hex-3-enyl]-5,6-dihydro-pyran-2-one | CHEMBL85451
Type:
Small organic molecule
Emp. Form.:
C25H34O5
Mol. Mass.:
414.5345
SMILES:
C\C(CCC1=C(C)CCCC1(C)C)=C/CCC1=CCC(OC1=O)C1=CC(=O)OC1O |c:4,t:17,25|
Structure:
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