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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50081154
Substrate
n/a
Meas. Tech.
ChEBML_71726
IC50
36±n/a nM
Citation
 DeVita, RJ; Goulet, MT; Wyvratt, MJ; Fisher, MH; Lo, JL; Yang, YT; Cheng, K; Smith, RG Investigation of the 4-O-alkylamine substituent of non-peptide quinolone GnRH receptor antagonists. Bioorg Med Chem Lett 9:2621-4 (1999) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50081154
Synonyms:
7-Chloro-3-(3,5-dimethyl-phenyl)-6-nitro-4-(piperidin-3-ylmethoxy)-1H-quinolin-2-one | CHEMBL89672
Type:
Small organic molecule
Emp. Form.:
C23H24ClN3O4
Mol. Mass.:
441.907
SMILES:
Cc1cc(C)cc(c1)-c1c(OCC2CCCNC2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O
Structure:
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