Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDihydrofolate reductase
LigandBDBM50081908
Substrate/Competitorn/a
Meas. Tech.ChEMBL_55095
Ki 300±n/a nM
Citation Chowdhury, SFVillamor, VBGuerrero, RHLeal, IBrun, RCroft, SLGoodman, JMMaes, LRuiz-Perez, LMPacanowska, DGGilbert, IH Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase. J Med Chem42:4300-12 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50081908
NameBDBM50081908
Synonyms:5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEMBL18967
TypeSmall organic molecule
Emp. Form.C12H14N4O
Mol. Mass.230.2658
SMILESCOc1cccc(Cc2cnc(N)nc2N)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a