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TargetDihydrofolate reductase
LigandBDBM50081918
Substrate/Competitorn/a
Meas. Tech.ChEMBL_53497
Ki 6.4±n/a nM
Citation Chowdhury, SFVillamor, VBGuerrero, RHLeal, IBrun, RCroft, SLGoodman, JMMaes, LRuiz-Perez, LMPacanowska, DGGilbert, IH Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase. J Med Chem42:4300-12 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50081918
NameBDBM50081918
Synonyms:5-(4-Propoxy-benzyl)-pyrimidine-2,4-diamine | CHEMBL326989
TypeSmall organic molecule
Emp. Form.C14H18N4O
Mol. Mass.258.3189
SMILESCCCOc1ccc(Cc2cnc(N)nc2N)cc1
Structure
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