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TargetDihydrofolate reductase
LigandBDBM50081909
Substrate/Competitorn/a
Meas. Tech.ChEMBL_54288
Ki 1000±n/a nM
Citation Chowdhury, SFVillamor, VBGuerrero, RHLeal, IBrun, RCroft, SLGoodman, JMMaes, LRuiz-Perez, LMPacanowska, DGGilbert, IH Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase. J Med Chem42:4300-12 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50081909
NameBDBM50081909
Synonyms:5-(3-(benzyloxy)benzyl)pyrimidine-2,4-diamine | 5-(3-Benzyloxy-benzyl)-pyrimidine-2,4-diamine | CHEMBL274031
TypeSmall organic molecule
Emp. Form.C18H18N4O
Mol. Mass.306.3617
SMILESNc1ncc(Cc2cccc(OCc3ccccc3)c2)c(N)n1
Structure
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