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Target
Delta-type opioid receptor
Ligand
BDBM50137562
Substrate
n/a
Meas. Tech.
ChEMBL_145326 (CHEMBL750414)
IC50
>10000±n/a nM
Citation
 Kawamoto, H; Ozaki, S; Itoh, Y; Miyaji, M; Arai, S; Nakashima, H; Kato, T; Ohta, H; Iwasawa, Y Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-one (J-113397). J Med Chem 42:5061-3 (2000) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50137562
Synonyms:
1-(1-Benzyl-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one | CHEMBL300616
Type:
Small organic molecule
Emp. Form.:
C19H21N3O
Mol. Mass.:
307.3895
SMILES:
O=c1[nH]c2ccccc2n1C1CCN(Cc2ccccc2)CC1
Structure:
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