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Target
Chymase
Ligand
BDBM50085339
Substrate
n/a
Meas. Tech.
ChEBML_197655
IC50
400±n/a nM
Citation
 Hayashi, Y; Iijima, K; Katada, J; Kiso, Y Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors. Bioorg Med Chem Lett 10:199-201 (2000) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM50085339
Synonyms:
((S)-1-Benzyl-3-chloro-2-oxo-propyl)-carbamic acid benzyl ester | CHEMBL303579 | acs.jmedchem.1c00409_ST.138
Type:
Small organic molecule
Emp. Form.:
C18H18ClNO3
Mol. Mass.:
331.793
SMILES:
ClCC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
Structure:
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