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TargetAdrenergic receptor alpha
LigandBDBM50085683
Substrate/Competitorn/a
Meas. Tech.ChEMBL_33684
Ki 0.015±n/a nM
Citation Ross, TMJetter, MCMcDonnell, MEBoyd, REConnelly, CDMartinez, RPLewis, MACodd, EERaffa, RBReitz, AB Alpha(2) adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydro-thianaphthene as a high-affinity ligand for the alpha(2D) adrenergic receptor. J Med Chem43:1423-6 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Adrenergic receptor alpha
Name:Adrenergic receptor alpha
Synonyms:Adrenaline 2 | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | Alpha2 Adrenoreceptor | CA2-47 | adrenergic Alpha2A
Type:G-protein coupled receptor
Mol. Mass.:48961.69
Organism:Rattus norvegicus (rat)
Description:Partially purified membrane from rat cortex was used in assays.
Residue:450
Sequence:
MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSS
IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGG
QQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACS
APPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSE
HAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKAS
RWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSS
LNPVIYTIFNHDFRRAFKKILCRGDRKRIV
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  Blast E-value cutoff:
BDBM50085683
NameBDBM50085683
Synonyms:(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole | 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole | CHEMBL778 | DEXMEDETOMIDINE | MPV 1440
TypeSmall organic molecule
Emp. Form.C13H16N2
Mol. Mass.200.2795
SMILESC[C@H](c1cnc[nH]1)c1cccc(C)c1C
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a