Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50087644
Substrate
n/a
Meas. Tech.
ChEBML_212707
IC50
169±n/a nM
Citation
 Tamura, SY; Levy, OE; Uong, TH; Reiner, JE; Goldman, EA; Ho, JZ; Cohen, CR; Bergum, PW; Nutt, RF; Brunck, TK; Semple, JE Guanylpiperidine peptidomimetics: potent and selective bis-cation inhibitors of factor Xa. Bioorg Med Chem Lett 10:745-9 (2000) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50087644
Synonyms:
(R)-N-[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-methyl]-3-(1-carbamimidoyl-piperidin-4-yl)-2-phenylmethanesulfonylamino-propionamide; TFA | CHEMBL162399
Type:
Small organic molecule
Emp. Form.:
C24H39N9O5S
Mol. Mass.:
565.689
SMILES:
NC(=N)N1CCC(C[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)CC1
Structure:
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