Reaction Details Report a problem with these data
Target
Interstitial collagenase
Ligand
BDBM50088068
Substrate
n/a
Meas. Tech.
ChEMBL_106145 (CHEMBL718692)
Ki
43±n/a nM
Citation
 Scozzafava, A; Supuran, CT Protease inhibitors: synthesis of potent bacterial collagenase and matrix metalloproteinase inhibitors incorporating N-4-nitrobenzylsulfonylglycine hydroxamate moieties. J Med Chem 43:1858-65 (2000) [PubMed]  Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50088068
Synonyms:
2-[1-(4-nitro-benzyl)-(sulfonyl-(4-fluorobenzene))-ureido]-N-Hydroxy-acetamide | CHEMBL300807
Type:
Small organic molecule
Emp. Form.:
C16H15FN4O7S
Mol. Mass.:
426.376
SMILES:
ONC(=O)CN(Cc1ccc(cc1)[N+]([O-])=O)C(=O)NS(=O)(=O)c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: