Reaction Details Report a problem with these data
Target
72 kDa type IV collagenase
Ligand
BDBM50090346
Substrate
n/a
Meas. Tech.
ChEBML_104391
IC50
>10000±n/a nM
Citation
Salvino, JM; Mathew, R; Kiesow, T; Narensingh, R; Mason, HJ; Dodd, A; Groneberg, R; Burns, CJ; McGeehan, G; Kline, J; Orton, E; Tang, SY; Morrisette, M; Labaudininiere, R Solid-phase synthesis of an arylsulfone hydroxamate library. Bioorg Med Chem Lett 10:1637-40 (2000) [PubMed] Article
More Info.:
Target
Name:
72 kDa type IV collagenase
Synonyms:
72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1
Type:
Enzyme
Mol. Mass.:
73870.36
Organism:
Homo sapiens (Human)
Description:
P08253
Residue:
660
Sequence:
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
Inhibitor
Name:
BDBM50090346
Synonyms:
3-(3-Cyclopentyloxy-4-methoxy-benzenesulfonyl)-N-hydroxy-3-[3-(4-methoxy-phenoxy)-phenyl]-propionamide | CHEMBL42104
Type:
Small organic molecule
Emp. Form.:
C28H31NO8S
Mol. Mass.:
541.613
SMILES:
COc1ccc(Oc2cccc(c2)C(CC(=O)NO)S(=O)(=O)c2ccc(OC)c(OC3CCCC3)c2)cc1