Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50090396
Substrate
n/a
Meas. Tech.
ChEBML_143994
IC50
31±n/a nM
Citation
 McNally, JJ; Youngman, MA; Lovenberg, TW; Nepomuceno, D; Wilson, S; Dax, SL N-acylated alpha-(3-pyridylmethyl)-beta-aminotetralin antagoinists of the human neuropeptide Y Y5 receptor. Bioorg Med Chem Lett 10:1641-3 (2000) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50090396
Synonyms:
CHEMBL44036 | [4-(6-Fluoro-1-pyridin-3-ylmethyl-1,2,3,4-tetrahydro-naphthalen-2-ylcarbamoyl)-cyclohexylmethyl]-carbamic acid phenyl ester
Type:
Small organic molecule
Emp. Form.:
C31H34FN3O3
Mol. Mass.:
515.6184
SMILES:
Fc1ccc2C(Cc3cccnc3)C(CCc2c1)NC(=O)[C@H]1CC[C@H](CNC(=O)Oc2ccccc2)CC1 |wU:21.23,wD:24.27,(-.63,-10.39,;.71,-9.64,;.72,-8.1,;2.05,-7.33,;3.38,-8.1,;4.72,-7.36,;4.74,-5.82,;3.39,-5.05,;3.39,-3.51,;2.05,-2.74,;.75,-3.51,;.75,-5.05,;2.05,-5.82,;6.04,-8.13,;6.04,-9.67,;4.7,-10.44,;3.37,-9.64,;2.04,-10.41,;7.38,-7.36,;8.71,-8.13,;8.71,-9.67,;10.06,-7.36,;10.06,-5.84,;11.39,-5.07,;12.74,-5.84,;14.07,-5.09,;15.4,-5.86,;16.74,-5.12,;16.75,-3.58,;18.06,-5.89,;19.39,-5.12,;19.37,-3.58,;20.68,-2.78,;22.03,-3.55,;22.05,-5.09,;20.72,-5.86,;12.72,-7.38,;11.39,-8.15,)|
Structure:
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