Reaction Details Report a problem with these data
Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50090590
Substrate
n/a
Meas. Tech.
ChEBML_71737
IC50
360±n/a nM
Citation
 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituents. Bioorg Med Chem Lett 10:1723-7 (2000) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50090590
Synonyms:
7-Chloro-3-(2-chloro-phenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one | CHEMBL274952
Type:
Small organic molecule
Emp. Form.:
C22H21Cl2N3O4
Mol. Mass.:
462.326
SMILES:
[O-][N+](=O)c1cc2c(OCCC3CCCCN3)c(-c3ccccc3Cl)c(=[OH+])[n-]c2cc1Cl |(4.91,-4.97,;4.91,-6.51,;3.58,-7.28,;6.24,-7.28,;7.57,-6.49,;8.91,-7.26,;10.24,-6.49,;10.24,-4.95,;8.91,-4.18,;8.91,-2.64,;7.57,-1.87,;6.25,-2.64,;4.91,-1.87,;4.92,-.33,;6.26,.44,;7.58,-.33,;11.58,-7.26,;12.91,-6.51,;12.91,-4.98,;14.24,-4.21,;15.59,-4.98,;15.57,-6.52,;14.24,-7.29,;14.24,-8.83,;11.58,-8.82,;12.91,-9.59,;10.24,-9.59,;8.9,-8.8,;7.57,-9.59,;6.24,-8.82,;4.91,-9.59,)|
Structure:
Search PDB for entries with ligand similarity: