Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50090771
Substrate
n/a
Meas. Tech.
ChEMBL_1206 (CHEMBL615972)
Ki
0.3±n/a nM
Citation
 Hammarberg, E; Nordvall, G; Leideborg, R; Nylöf, M; Hanson, S; Johansson, L; Thorberg, SO; Tolf, BR; Jerning, E; Svantesson, GT; Mohell, N; Ahlgren, C; Westlind-Danielsson, A; Csöregh, I; Johansson, R Synthesis of novel 5-substituted 3-amino-3,4-dihydro-2H-1-benzopyran derivatives and their interactions with the 5-HT1A receptor. J Med Chem 43:2837-50 (2000) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50090771
Synonyms:
(R)-1-[3-(Isopropyl-propyl-amino)-chroman-5-yl]-ethanone | (S)-1-[3-(Isopropyl-propyl-amino)-chroman-5-yl]-ethanone | CHEMBL97398
Type:
Small organic molecule
Emp. Form.:
C17H25NO2
Mol. Mass.:
275.3859
SMILES:
CCCN(C(C)C)C1COc2cccc(C(C)=O)c2C1
Structure:
Search PDB for entries with ligand similarity: