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TargetAtrial natriuretic peptide receptor
LigandBDBM50091753
Substrate/Competitorn/a
Meas. Tech.ChEBML_34991
Ki 0.059000±n/a nM
Citation Veale, CAAlford, VCAharony, DBanville, DLBialecki, RABrown, FJDamewood, JRDantzman, CLEdwards, PDJacobs, RTMauger, RCMurphy, MMPalmer, WPine, KKRumsey, WLGarcia-Davenport, LEShaw, ASteelman, GBSurian, JMVacek, EP The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett10:1949-52 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Atrial natriuretic peptide receptor
Name:Atrial natriuretic peptide receptor
Synonyms:ANP-C | ANPRC | Atrial natriuretic peptide C-type receptor | Atrial natriuretic peptide clearance receptor | Atrial natriuretic peptide receptor C | NPR-C
Type:PROTEIN
Mol. Mass.:59805.12
Organism:Homo sapiens
Description:ChEMBL_34991
Residue:541
Sequence:
MPSLLVLTFSPCVLLGWALLAGGTGGGGVGGGGGGAGIGGGRQEREALPPQKIEVLVLLP
QDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRALFSLVDRV
AAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRVAPA
YAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSIYSFDETK
DLDLEDIVRNIQASERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDG
SWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNMEDYVNMFVEG
FHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVIA
MTDVEAGTQEVIGDYFGKEGRFEMRPNVKYPWGPLKLRIDENRIVEHTNSSPCKSSGGLE
ESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRTQQEESNLGKHRELREDSIRSHFSV
A
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50091753
NameBDBM50091753
Synonyms:CHEMBL405854 | H-Ser-Leu-Arg-Arg-Ser-Ser-cyclic(Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys)-Asn-Ser-Phe-Arg-Tyr-OH
TypeSmall organic molecule
Emp. Form.C127H203N45O39S3
Mol. Mass.3080.444
SMILESCC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CSSC[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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