Reaction Details Report a problem with these data
Target
Erythropoietin receptor
Ligand
BDBM50091858
Substrate
n/a
Meas. Tech.
ChEMBL_67869 (CHEMBL679895)
IC50
5000±n/a nM
Citation
 Connolly, PJ; Wetter, SK; Murray, WV; Johnson, DL; McMahon, FJ; Farrell, FX; Tullai, J; Jolliffe, LK Synthesis and erythropoietin receptor binding affinities of N,N-disubstituted amino acids. Bioorg Med Chem Lett 10:1995-9 (2001) [PubMed]  Article 
Target
Name:
Erythropoietin receptor
Synonyms:
EPO-R | EPOR | EPOR_HUMAN
Type:
PROTEIN
Mol. Mass.:
55040.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_67864
Residue:
508
Sequence:
MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGLSDGPYSNPYENSLIPAAEPLPPSYVACS
  
Inhibitor
Name:
BDBM50091858
Synonyms:
CHEMBL440818 | GGQPK-cyclic-(CVWTLPGFHC)-YSTGG-NH2
Type:
Small organic molecule
Emp. Form.:
C94H134N26O25S2
Mol. Mass.:
2092.359
SMILES:
CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)CN)C(C)C)[C@@H](C)O
Structure:
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