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Target
Transcription factor Jun
Ligand
BDBM50092880
Substrate
n/a
Meas. Tech.
ChEMBL_28876 (CHEMBL645946)
IC50
600±n/a nM
Citation
 Palanki, MS; Erdman, PE; Gayo-Fung, LM; Shevlin, GI; Sullivan, RW; Goldman, ME; Ransone, LJ; Bennett, BL; Manning, AM; Suto, MJ Inhibitors of NF-kappaB and AP-1 gene expression: SAR studies on the pyrimidine portion of 2-chloro-4-trifluoromethylpyrimidine-5-[N-(3', 5'-bis(trifluoromethyl)phenyl)carboxamide]. J Med Chem 43:3995-4004 (2000) [PubMed]  Article 
Target
Name:
Transcription factor Jun
Synonyms:
AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:
n/a
Mol. Mass.:
35683.24
Organism:
Homo sapiens (Human)
Description:
P05412
Residue:
331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
  
Inhibitor
Name:
BDBM50092880
Synonyms:
2-Chloro-4-pentafluoroethyl-pyrimidine-5-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide | CHEMBL421280
Type:
Small organic molecule
Emp. Form.:
C15H5ClF11N3O
Mol. Mass.:
487.655
SMILES:
FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)C(F)(F)F)cc(c1)C(F)(F)F
Structure:
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