Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50092990
Substrate
n/a
Meas. Tech.
ChEBML_138412
Ki
57±n/a nM
Citation
 Kozlowski, JA; Lowe, DB; Guzik, HS; Zhou, G; Ruperto, VB; Duffy, RA; McQuade, R; Crosby, G; Taylor, LA; Billard, W; Binch, H; Lachowicz, JE Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor. Bioorg Med Chem Lett 10:2255-7 (2001) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50092990
Synonyms:
1-[1-(4-Benzenesulfonyl-phenyl)-ethyl]-piperazine | CHEMBL71088
Type:
Small organic molecule
Emp. Form.:
C18H22N2O2S
Mol. Mass.:
330.444
SMILES:
CC(N1CCNCC1)c1ccc(cc1)S(=O)(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: