Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50093690
Substrate
n/a
Meas. Tech.
ChEMBL_143676 (CHEMBL857689)
IC50
5200±n/a nM
Citation
 Norman, MH; Chen, N; Chen, Z; Fotsch, C; Hale, C; Han, N; Hurt, R; Jenkins, T; Kincaid, J; Liu, L; Lu, Y; Moreno, O; Santora, VJ; Sonnenberg, JD; Karbon, W Structure-activity relationships of a series of pyrrolo[3,2-d]pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists. J Med Chem 43:4288-312 (2000) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50093690
Synonyms:
CHEMBL137356 | Dimethyl-[1-(2-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-piperidin-2-ylmethyl]-amine
Type:
Small organic molecule
Emp. Form.:
C21H27N5
Mol. Mass.:
349.4726
SMILES:
CN(C)CC1CCCCN1c1nc(C)nc2cc([nH]c12)-c1ccccc1
Structure:
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