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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50093894
Substrate
n/a
Meas. Tech.
ChEBML_139909
EC50
376±n/a nM
Citation
 Zlotos, DP; Buller, S; Tränkle, C; Mohr, K Bisquaternary caracurine V derivatives as allosteric modulators of ligand binding to M2 acetylcholine receptors. Bioorg Med Chem Lett 10:2529-32 (2001) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_PIG | CHRM2 | Cholinergic, muscarinic | GPM2 | LOC100715343 | Muscarinic acetylcholine receptor M2 | Muscarinic receptor 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51688.65
Organism:
GUINEA PIG
Description:
Cholinergic, muscarinic 0 GUINEA PIG::P06199
Residue:
466
Sequence:
MNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRIVKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50093894
Synonyms:
CHEMBL385915 | Caracurine V derivative
Type:
Small organic molecule
Emp. Form.:
C60H60N6O6
Mol. Mass.:
961.1539
SMILES:
O=C1N(CCC[N+]23CCC45[C@@H]2C[C@@H]2[C@@H]6[C@@H]4N([C@@H]4OCC=C7C[N+]8(CCCN9C(=O)c%10ccccc%10C9=O)CCC9%10[C@@H]8C[C@@H]7[C@@H]4[C@@H]9N([C@@H]6OCC=C2C3)c2ccccc%102)c2ccccc52)C(=O)c2ccccc12 |c:58,t:21|
Structure:
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