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Target
Adenosine kinase
Ligand
BDBM50095384
Substrate
n/a
Meas. Tech.
ChEMBL_31128 (CHEMBL643556)
IC50
5±n/a nM
Citation
 Cowart, M; Lee, CH; Gfesser, GA; Bayburt, EK; Bhagwat, SS; Stewart, AO; Yu, H; Kohlhaas, KL; McGaraughty, S; Wismer, CT; Mikusa, J; Zhu, C; Alexander, KM; Jarvis, MF; Kowaluk, EA Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors. Bioorg Med Chem Lett 11:83-6 (2001) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADENOSINE | ADK_RAT | Adenosine 5-phosphotransferase | Adenosine Kinase (AK) | Adenosine kinase | Adk
Type:
Enzyme
Mol. Mass.:
40130.14
Organism:
Rattus norvegicus (rat)
Description:
Rat brain cytosol as enzyme source.
Residue:
361
Sequence:
MAAADEPKPKKLKVEAPEALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSMKVAQWMIQEPHRAATFFGCIGIDKFGEILKSKAADAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLENNWMLVEKARVYYIAGFFLTVSPESVLKVARYAAENNRTFTLNLSAPFISQFFKEALMEVMPYVDILFGNETEAATFAREQGFETKDIKEIARKTQALPKVNSKRQRTVIFTQGRDDTIVATGNDVTAFPVLDQNQEEIVDTNGAGDAFVGGFLSQLVSNKPLTECIRAGHYAASVIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50095384
Synonyms:
5-(3-Bromo-phenyl)-7-(4-dimethylamino-phenyl)-pyrido[2,3-d]pyrimidin-4-ylamine | CHEMBL68749
Type:
Small organic molecule
Emp. Form.:
C21H18BrN5
Mol. Mass.:
420.305
SMILES:
CN(C)c1ccc(cc1)-c1cc(-c2cccc(Br)c2)c2c(N)ncnc2n1
Structure:
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