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Target
AMP deaminase 3
Ligand
BDBM50096157
Substrate
n/a
Meas. Tech.
ChEMBL_31886 (CHEMBL645676)
Ki
500±n/a nM
Citation
 Kasibhatla, SR; Bookser, BC; Xiao, W; Erion, MD AMP deaminase inhibitors. 5. Design, synthesis, and SAR of a highly potent inhibitor series. J Med Chem 44:613-8 (2001) [PubMed]  Article 
Target
Name:
AMP deaminase 3
Synonyms:
AMP deaminase 3 | AMP deaminase 3 (hAMPD3) | AMPD3 | AMPD3_HUMAN
Type:
Protein
Mol. Mass.:
88818.80
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
767
Sequence:
MPRQFPKLNISEVDEQVRLLAEKVFAKVLREEDSKDALSLFTVPEDCPIGQKEAKERELQKELAEQKSVETAKRKKSFKMIRSQSLSLQMPPQQDWKGPPAASPAMSPTTPVVTGATSLPTPAPYAMPEFQRVTISGDYCAGITLEDYEQAAKSLAKALMIREKYARLAYHRFPRITSQYLGHPRADTAPPEEGLPDFHPPPLPQEDPYCLDDAPPNLDYLVHMQGGILFVYDNKKMLEHQEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFDGLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSPNPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALTN
  
Inhibitor
Name:
BDBM50096157
Synonyms:
1,3-Dichloro-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester | CHEMBL154259
Type:
Small organic molecule
Emp. Form.:
C21H24Cl2N4O3
Mol. Mass.:
451.346
SMILES:
CCOC(=O)c1c(Cl)c(CCn2cnc3C(O)CNC=Nc23)c2CCCCc2c1Cl |c:19|
Structure:
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