Reaction Details Report a problem with these data
Target
Retinoic acid receptor alpha
Ligand
BDBM50097823
Substrate
n/a
Meas. Tech.
ChEMBL_195314 (CHEMBL799869)
IC50
210±n/a nM
Citation
 Beard, RL; Klein, ES; Standeven, AM; Escobar, M; Chandraratna, RA Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity. Bioorg Med Chem Lett 11:765-8 (2001) [PubMed]  Article 
Target
Name:
Retinoic acid receptor alpha
Synonyms:
NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic acid receptor alpha | Retinoic acid receptor alpha/Retinoid X receptor alpha | Retinoid X receptor gamma/retinoic acid receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50778.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1466191
Residue:
462
Sequence:
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
  
Inhibitor
Name:
BDBM50097823
Synonyms:
4-[(E)-4-(6,6-Dimethyl-2-p-tolyl-cyclohex-1-enyl)-but-3-en-1-ynyl]-benzoic acid | CHEMBL349018
Type:
Small organic molecule
Emp. Form.:
C26H26O2
Mol. Mass.:
370.4834
SMILES:
Cc1ccc(cc1)C1=C(\C=C\C#Cc2ccc(cc2)C(O)=O)C(C)(C)CCC1 |c:8|
Structure:
Search PDB for entries with ligand similarity: