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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50098088
Substrate
n/a
Meas. Tech.
ChEBML_139761
Ki
14±n/a nM
Citation
 Wang, Y; Chackalamannil, S; Chang, W; Greenlee, W; Ruperto, V; Duffy, RA; McQuade, R; Lachowicz, JE Design and synthesis of ether analogues as potent and selective M2 muscarinic receptor antagonists. Bioorg Med Chem Lett 11:891-4 (2001) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50098088
Synonyms:
4-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenoxy]-1'-(propane-2-sulfonyl)-[1,4']bipiperidinyl | CHEMBL169313
Type:
Small organic molecule
Emp. Form.:
C26H34N2O7S2
Mol. Mass.:
550.687
SMILES:
CC(C)S(=O)(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(cc1)S(=O)(=O)c1ccc2OCOc2c1
Structure:
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