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TargetMuscarinic acetylcholine receptor M2
LigandBDBM50098089
Substrate/Competitorn/a
Meas. Tech.ChEBML_139761
Ki 3.2±n/a nM
Citation Wang, YChackalamannil, SChang, WGreenlee, WRuperto, VDuffy, RAMcQuade, RLachowicz, JE Design and synthesis of ether analogues as potent and selective M2 muscarinic receptor antagonists. Bioorg Med Chem Lett11:891-4 (2001) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M2
Name:Muscarinic acetylcholine receptor M2 and M5
Synonyms:CHRM2 | Cholinergic, muscarinic M2 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:GPCR
Mol. Mass.:51730.61
Organism:Homo sapiens (Human)
Description:P08172
Residue:466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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  Blast E-value cutoff:
BDBM50098089
NameBDBM50098089
Synonyms:4-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenoxy]-[1,4']bipiperidinyl-1'-carboxylic acid isopropyl ester | CHEMBL169876
TypeSmall organic molecule
Emp. Form.C27H34N2O7S
Mol. Mass.530.633
SMILESCC(C)OC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(cc1)S(=O)(=O)c1ccc2OCOc2c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a