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Target
Chymase
Ligand
BDBM50101135
Substrate
n/a
Meas. Tech.
ChEBML_197650
IC50
2±n/a nM
Citation
 Aoyama, Y; Uenaka, M; Konoike, T; Hayasaki-Kajiwara, Y; Naya, N; Nakajima, M Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones. Bioorg Med Chem Lett 11:1691-4 (2001) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM50101135
Synonyms:
1,3-Bis-(4-methoxy-benzyl)-[1,3]diazetidine-2,4-dione | CHEMBL48083
Type:
Small organic molecule
Emp. Form.:
C18H18N2O4
Mol. Mass.:
326.3465
SMILES:
COc1ccc(CN2C(=O)N(Cc3ccc(OC)cc3)C2=O)cc1
Structure:
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